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Plasma immunoreactive endothelin-1 in primary hyperaldosteronism.

F Veglio·R Melchio·F Rabbia·L Chiandussi
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Abstract

This study evaluated the assessment of plasma endothelin-1 (ET-1) levels in primary aldosteronism and its correlation with other vasoactive hormones such as renin, aldosterone, catecholamines, arginine-vasopressin, and atrial natriuretic peptide. Plasma ET-1 was measured in 12 patients with primary aldosteronism (five adenomas and seven primary hyperplasia) and in 15 normal subjects. No significant differences were found in plasma ET-1 between controls and hypertensive patients both in adenoma and primary adrenal hyperplasia (8.8 + 1.6 pg/mL v 6.2 + 1.4 pg/mL v 6.5 + 1.0 pg/mL, P = NS, respectively). Further, no significant correlations were found among ET-1 and vasoactive hormones. In conclusion, these findings show that there are no differences in ET-1 levels between primary aldosteronism patients and healthy subjects. Circulating ET-1 is not involved in the hypertension in primary aldosteronism.

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AdenomaAdrenal Gland NeoplasmsAdrenal GlandsEndothelinsFemaleHumansHyperaldosteronismHyperplasiaMaleMiddle AgedJournal Article

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F Veglio, R Melchio, F Rabbia, L Chiandussi. 1994. Plasma immunoreactive endothelin-1 in primary hyperaldosteronism.. https://doi.org/10.1093/ajh%2F7.6.559

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