Calcium signaling in restricted diffusion spaces.

G J Kargacin

doi:10.1016/s0006-3495(94)80477-1

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Calcium signaling in restricted diffusion spaces.

G J Kargacin

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Abstract

One- and two-dimensional models of Ca2+ diffusion and regulation were developed and used to study the magnitudes and the spatial and temporal characteristics of the Ca2+ transients that are likely to develop in smooth muscle cells in restricted diffusion spaces between the plasma membrane and intracellular organelles. Simulations with the models showed that high [Ca2+] (on the order of several microM) can develop in such spaces and persist for 100-200 ms. These Ca2+ transients could: 1) facilitate the coupling of Ca2+ influx to intracellular Ca2+ release; 2) provide a mechanism for the regulation of stored Ca2+ that does not affect the contractile state of smooth muscle; 3) locally activate specific signal transduction pathways, before, or without activating other Ca2+ dependent pathways in the central cytoplasm of the cell. The latter possibility suggests that independent enzymatic processes in cells could be differentially regulated by the same intracellular second messenger.

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Animals Calcium Cell Membrane Diffusion Kinetics Mathematics Models, Biological Muscle, Smooth Sarcoplasmic Reticulum Signal Transduction Software Time Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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G J Kargacin. 1994. Calcium signaling in restricted diffusion spaces.. https://doi.org/10.1016/s0006-3495(94)80477-1

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