Synaptic plasticity: LTP and LTD.

M F Bear; R C Malenka

doi:10.1016/0959-4388(94)90101-5

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PubMed · 7919934

Synaptic plasticity: LTP and LTD.

M F Bear·R C Malenka

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Abstract

Long-term potentiation (LTP) is a synaptic enhancement that follows brief, high-frequency electrical stimulation in the hippocampus and neocortex. Recent evidence suggests that induction of LTP may require, in addition to postsynaptic Ca2+ entry, activation of metabotropic glutamate receptors and the generation of diffusible intercellular messengers. A new form of synaptic plasticity, homosynaptic long-term depression (LTD) has also recently been documented, which, like LTP, requires Ca2+ entry through the NMDA receptor. Current work suggests that this LTD is a reversal of LTP, and vice versa, and that the mechanisms of LTP and LTD may converge at the level of specific phosphoproteins.

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Animals Humans Long-Term Potentiation Neuronal Plasticity Receptors, Metabotropic Glutamate Second Messenger Systems Synapses Journal Article Review

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M F Bear, R C Malenka. 1994. Synaptic plasticity: LTP and LTD.. https://doi.org/10.1016/0959-4388(94)90101-5

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