Pit-1 and pituitary function.

R W Pfäffle; J S Parks; M R Brown; G Heimann

doi:10.1515/jpem.1993.6.3-4.229

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Pit-1 and pituitary function.

R W Pfäffle·J S Parks·M R Brown·G Heimann

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Abstract

Several patients with pituitary dwarfism and a variable degree of hypothyroidism have been shown to have mutations in their Pit-1 gene. Pit-1 activates transcription of the growth hormone and prolactin genes and is necessary for the control of the beta-TSH gene transcription. The various mutations have different effects on the DNA binding and transactivating properties of Pit-1. Multiple pituitary hormone deficiency due to Pit-1 mutations is inherited either dominantly or recessively depending on the DNA binding properties of the mutant protein. The comparison of pheno- and genotype in patients with multiple pituitary hormone deficiency provides some insight into the function of the Pit-1 protein.

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Animals DNA-Binding Proteins Humans Mutation Pituitary Gland Pituitary Hormones Transcription Factor Pit-1 Transcription Factors Journal Article Review

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R W Pfäffle, J S Parks, M R Brown, G Heimann. Pit-1 and pituitary function.. https://doi.org/10.1515/jpem.1993.6.3-4.229

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