Adaptive evolution of highly mutable loci in pathogenic bacteria.

E R Moxon; P B Rainey; M A Nowak; R E Lenski

doi:10.1016/s0960-9822(00)00005-1

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Adaptive evolution of highly mutable loci in pathogenic bacteria.

E R Moxon·P B Rainey·M A Nowak·R E Lenski

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Abstract

Bacteria have specific loci that are highly mutable. We argue that the coexistence within bacterial genomes of such 'contingency' genes with high mutation rates, and 'housekeeping' genes with low mutation rates, is the result of adaptive evolution, and facilitates the efficient exploration of phenotypic solutions to unpredictable aspects of the host environment while minimizing deleterious effects on fitness.

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Animals Bacteria Base Sequence Biological Evolution DNA, Bacterial Gene Conversion Genes, Bacterial Haemophilus influenzae Humans Models, Genetic Molecular Sequence Data Mutation Phenotype Recombination, Genetic Repetitive Sequences, Nucleic Acid Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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E R Moxon, P B Rainey, M A Nowak, R E Lenski. 1994-01-01. Adaptive evolution of highly mutable loci in pathogenic bacteria.. https://doi.org/10.1016/s0960-9822(00)00005-1

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