PubMed · 7924445
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C G Webster, J W Burnett. 1994. Gold dermatitis.. https://pubmed.ncbi.nlm.nih.gov/7924445/
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The purpose of this study was to determine the plasma concentrations of selected NSAIDs after topical gel administration and to determine the influence of the physicochemical characteristics of these drugs on transdermal absorption. Plasma concentrations of the drugs were determined using high performance liquid chromatography. The logP values obtained from literature for piroxicam, ketoprofen, naproxen, ibuprofen and indomethacin, (1.8, 0.97, 3.22, 3.6 and 3.8, respectively) correlated with the area under the plasma-time curve (AUC) values. The AUC values determined were 527.00 (piroxicam) 269. 45 (ketoprofen) 258.65 (naproxen) 243.22 (indomethacin) and 88.09 (ibuprofen) microg/ml per h. It was concluded that the most reliable parameter for transdermal absorption was the lipophilic character of a drug (logP value). The molecular mass, solubility constraint and percentage unionized moiety can only be used in combination with other properties in the prediction of possible transdermal drug delivery.
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To achieve a discontinuous drug delivery to the skin a new actively controlled transdermal system has been developed. The system consists of a tube shaped drug reservoir in combination with an electronic circuit and a gas producing cell. A magnetic switch was used to control the onset of the production of hydrogen gas. The gas was generated with a constant rate. The tube reservoir was filled with a solution of nitroglycerin in propylene glycol. A discontinuous distribution of nitroglycerin in the reservoir is responsible for the pulsed release. 2, 3, 4, or 6 fractions of nitroglycerin solution, which were separated from each other by sections with air, were filled into the tube reservoir. The release studies show that the release patterns directly reflect the number of doses, which were filled into the tube. A lag time of about 60 min was obtained, if the gas production is regulated by a 2.7 kOmega resistor. The drug is released during the pre-programmed time intervals within 6-7 h. Between the time intervals no drug release occurs.