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Trinucleotide repeat polymorphism within the human antithrombin gene (AT3): allele frequency data for three population groups.

J S Waye·B Eng·H Y Ni·M A Blajchman·G Carmody
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Abstract

The fifth intron of the human antithrombin gene (AT3) of chromosome 1q23 contains a highly polymorphic short tandem repeat based on the trinucleotide repeat [ATT]. Alleles range in size from [ATT]5 to [ATT]18, and can be typed using the polymerase chain reaction. Here we report allele frequency population data for Caucasians, Blacks and Southeast Asians. Statistical analyses demonstrate consistency with Hardy-Weinberg equilibrium for all three databases, and that the allele frequencies of all three population groups are significantly different from each other. This locus reveals 76% to 87% heterozygosity and therefore may be useful for forensic identity testing and paternity determination.

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AllelesAntithrombin IIIAsian PeopleBase SequenceBlack PeopleDNAGene FrequencyHeterozygoteHumansMolecular Sequence DataNucleotidesPolymerase Chain ReactionPolymorphism, GeneticRepetitive Sequences, Nucleic AcidWhite PeopleComparative StudyJournal Article

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J S Waye, B Eng, H Y Ni, M A Blajchman, G Carmody. 1994. Trinucleotide repeat polymorphism within the human antithrombin gene (AT3): allele frequency data for three population groups.. https://doi.org/10.1006/mcpr.1994.1020

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