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PubMed · 7946051

Th1 versus Th2 responses in AIDS.

S Romagnani·E Maggi
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Abstract

During the past two years, a simple theory that seeks to explain what causes the progression of HIV-infected individuals to AIDS has been gaining support. The theory holds that HIV-infected people switch from a T-helper type 1 (Th1) to a T-helper type 2 (Th2) state as the disease progresses. However the experimental data do not support the concept that a Th1/Th2 switch occurs in the majority of HIV-infected subjects, although it is conceivable that HIV-infected individuals who mount sustained and chronic Th2-type responses, as a result of allergic disorders and helminthic infestations, may undergo more active HIV replication and therefore progress faster to full-blown disease.

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Acquired Immunodeficiency SyndromeHIV InfectionsHIV-1HumansTh1 CellsTh2 CellsVirus ReplicationJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S Romagnani, E Maggi. 1994. Th1 versus Th2 responses in AIDS.. https://doi.org/10.1016/0952-7915(94)90150-3

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