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Sequence-specific impairment of learning by c-jun antisense oligonucleotides.

W Tischmeyer·R Grimm·H Schicknick·W Brysch·K H Schlingensiepen
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Abstract

Hybridization studies revealed a differential accumulation of c-jun and jun B mRNA in the hippocampus and cerebral cortex of rats trained on a foot-shock-motivated brightness discrimination. Supposing that early gene expression is functionally significant for plastic changes in the brain, we used antisense phosphorothioate oligodeoxynucleotides (S-ODN) in vivo to study effects of specific inhibition of c-jun and jun B gene expression on learning and memory formation in rat brain. Discrimination performance of rats was impaired after intrahippocampal injection of anti-c-jun S-ODN but not of anti-jun B S-ODN. These results imply that topically injected antisense oligonucleotides affect processes involved in learning and memory in a sequence-specific manner.

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AnimalsBase SequenceCerebral CortexDiscrimination, PsychologicalElectroshockGene ExpressionGenes, junHippocampusLearningMaleMemoryMolecular Sequence DataOligonucleotides, AntisenseRatsRats, WistarReference ValuesVisual PerceptionComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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W Tischmeyer, R Grimm, H Schicknick, W Brysch, K H Schlingensiepen. 1994-07-21. Sequence-specific impairment of learning by c-jun antisense oligonucleotides.. https://doi.org/10.1097/00001756-199407000-00023

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