Modeling cortical spreading depression.

J A Reggia; D Montgomery

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PubMed · 7950049

Modeling cortical spreading depression.

J A Reggia·D Montgomery

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Abstract

Cortical spreading depression is a wave of electrical silence and biochemical changes that spreads across the cerebral cortex. Recently there has been a growing recognition that it may be an important pathophysiological event in a number of neurological disorders. In this paper, we describe a reaction-diffusion model of the extracellular potassium changes that are a central part of this process. Simulations with the model show that an appropriate stimulus evokes a moving wave of increased potassium with many similarities to that seen experimentally. The resultant model is a useful computational tool for future study of the effects of spreading depression on the cortex.

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Computer Simulation Cortical Spreading Depression Diffusion Extracellular Space Humans Models, Neurological Potassium Journal Article Research Support, U.S. Gov't, P.H.S.

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J A Reggia, D Montgomery. 1994. Modeling cortical spreading depression.. https://pubmed.ncbi.nlm.nih.gov/7950049/

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