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Structure/function studies of lin-12/Notch proteins.

I Greenwald
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Abstract

The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown that the lin-12/Notch intracellular domain alone has the intrinsic signal-transducing activity of the intact protein, and that the role of the extracellular domain is to regulate this intrinsic activity. These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development.

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Amino Acid SequenceAnimalsAnkyrin RepeatCaenorhabditis elegansCaenorhabditis elegans ProteinsDrosophilaDrosophila ProteinsEmbryonic InductionGene Expression Regulation, DevelopmentalHelminth ProteinsHumansInsect HormonesMembrane ProteinsMultigene FamilyReceptors, NotchSignal TransductionStructure-Activity RelationshipJournal ArticleReview

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I Greenwald. 1994. Structure/function studies of lin-12/Notch proteins.. https://doi.org/10.1016/0959-437x(94)90072-b

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