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PubMed · 7958732

Miconazole as inflammatory agent--I. Cellular and pathophysiological effects.

S Hanada·J A Sertié·E Waisbich·L S Sudo
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Abstract

1. Subcutaneous injection of miconazole into the rat paw evoked an acute, circumscribed and long-lasting inflammation. 2. Miconazole edema presented two defined phases of rapid swelling. 3. Miconazole edema was antagonized by chlorpheniramine, dexamethasone and phenylbutazone. 4. This edema was 1.5-2 times more intense than edema due to econazole. 5. It is suggested that miconazole paw edema might be useful in the process of screening anti-inflammatory drugs.

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AnimalsEdemaInflammationLeukocyte CountMaleMiconazoleRatsRats, WistarJournal Article

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S Hanada, J A Sertié, E Waisbich, L S Sudo. 1994. Miconazole as inflammatory agent--I. Cellular and pathophysiological effects.. https://doi.org/10.1016/0306-3623(94)90250-x

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