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PubMed · 7959742

Identification, characterization, and physical mapping of 14 polymorphic simple sequence repeat markers on human chromosome 21.

S R Lowry·K Wilson·R Blazej·J Chiu·J Rine·E A Ostrander
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Abstract

Fourteen new dinucleotide repeat polymorphisms specific for human chromosome 21 have been identified, mapped, and characterized. The average heterozygosity of all markers was 0.66. The average PIC value was 0.61. The markers were mapped by STS content mapping of YACs previously assigned to chromosome 21. The correlation of polymorphic genetic markers with substantially complete physical maps should facilitate the identification of loci of interest on chromosome 21.

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Base SequenceChromosome MappingChromosomes, Artificial, YeastChromosomes, Human, Pair 21DNA PrimersGenetic MarkersHumansMolecular Sequence DataPolymerase Chain ReactionRepetitive Sequences, Nucleic AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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S R Lowry, K Wilson, R Blazej, J Chiu, J Rine, E A Ostrander. 1994. Identification, characterization, and physical mapping of 14 polymorphic simple sequence repeat markers on human chromosome 21.. https://doi.org/10.1006/geno.1994.1324

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