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Triangular test and randomized trials: practical problems in a small cell lung cancer trial.

J P Pignon·M Tarayre·A Auquier·R Arriagada·T Le Chevalier·P Ruffié·A Rivière·I Monnet·P Chomy·C Tuchais
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Abstract

The triangular test has been used to monitor survival data from a randomized trial in patients with small cell lung cancer. The results of consecutive interim analyses and the problems met by the data monitoring committee and the co-ordinators are described. The methods as well as the consequences of the early stopping on the analysis and the results of this trial are discussed. From this experience, we believe that statistical stopping rules--only one of the factors to be taken into account when deciding to stop a trial--should be used with caution. Independent data monitoring committees may be useful in helping to review the ongoing results and advise the participants in the trial.

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Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCisplatinCyclophosphamideData Interpretation, StatisticalDose-Response Relationship, DrugDoxorubicinDrug Administration ScheduleEtoposideHumansLung NeoplasmsMulticenter Studies as TopicRadiotherapy, AdjuvantRadiotherapy, High-EnergyRandomized Controlled Trials as TopicSurvival AnalysisSurvival RateClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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J P Pignon, M Tarayre, A Auquier, R Arriagada, T Le Chevalier, P Ruffié, A Rivière, I Monnet, P Chomy, C Tuchais. Triangular test and randomized trials: practical problems in a small cell lung cancer trial.. https://doi.org/10.1002/sim.4780131317

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