PubMed · 7974247
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1994-05-18. [Congress--we will work together].. https://pubmed.ncbi.nlm.nih.gov/7974247/
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BACKGROUNDIncreasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (iSDSE) have been detected worldwide.AIMWe aimed to investigate iSDSE infection incidence rates in Denmark during 2014-2024, and characterise the genomic population structure of a subset of iSDSE isolates and their antimicrobial resistance (AMR).METHODSUsing national register data, we estimated overall and sex-/age-stratified iSDSE incidences during 2014-2024, by retrospectively identifying cases of invasive infections with group C and G streptococci or S. dysgalactiae (including specified as subspecies equisimilis). From the voluntary national beta-haemolytic streptococci laboratory surveillance system, whole-genome-sequenced isolates from August 2020-September 2022 were used to investigate the iSDSE genomic population structure. Susceptibility to penicillin, erythromycin and clindamycin was determined and AMR genes identified.RESULTSDuring 2014-2024, iSDSE incidence rates increased significantly (linear trend analysis p < 0.001) with mean annual incidence ranging between 10.3 and 16.4 per 100,000, peaking in 2023. Incidence was higher in males, increasing with older age. Nearly 75% of the 1,223 iSDSE isolates belonged to four of 14 genetic clusters. Sequence types (STs) ST20 and ST17 were most prevalent, while emm-type stG62647, a variant associated internationally with higher virulence, dominated. All isolates were phenotypically susceptible to penicillin but approximately 10% were respectively erythromycin and clindamycin resistant. High erythromycin resistance prevalence (57%; 39/68), coinciding with gene ermA, occurred in one genetic cluster.CONCLUSIONThe findings illustrate the need for national registry-based surveillance to detect epidemiological changes and potential outbreaks. Further, continuous genomic surveillance can monitor the occurrence and expansion of genetic clades and AMR genes.
This study gives a descriptive analysis of 52 patients with type-I allergy to latex. Seventy-one percent of these cases were considered occupational, especially related to the health care sector (29 of 37 patients). Four patients had to change their jobs because of the allergy. Twenty-five percent presented initially with monosymptomatic contact urticaria, while 35% presented with hand eczema, which could only be explained by concomitant allergy to rubber chemicals in 35% of the cases. During the period from observation of initial symptoms until establishment of the diagnosis, several of the patients with monosymptomatic hand eczema developed additional type-I related symptoms. Not only latex-exposed patients with type-I-related symptoms, but also latex-exposed patients with hand eczema should be suspected for latex-allergy and tested with pricktests, latex-specific IgE and skin-provocation tests.
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