[Chromatin proteins binding vitamin E].

A A Kapralov; G V Donchenko; G V Petrova

PubMed · 7974844

[Chromatin proteins binding vitamin E].

Abstract

It was discovered that alpha-tocopherol binding with isolated chromatin is specific only when fraction of tocopherol-binding proteins from a nuclear extract with 1% triton X-100 is present. During the chromatography of chromatin incubated with [H] alpha-tocopherol on hydroxyapatite a specific binding activity was present only in fraction eluted with 2M NaCl + 5M urea. Quantitative changes in the protein content of this fraction during a hypovitaminosis are found. It is shown that vitamin E can effect the RNA polymerase activity of a nuclear matrix in the in vitro assays. It is suggested that the presence of tocopherol-binding proteins of chromatin in necessary for such an action of alpha-tocopherol.

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Chromatin DNA-Directed RNA Polymerases Nucleoproteins Protein Binding Transcription, Genetic Vitamin E English Abstract Journal Article

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A A Kapralov, G V Donchenko, G V Petrova. [Chromatin proteins binding vitamin E].. https://pubmed.ncbi.nlm.nih.gov/7974844/

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