Statistical analysis of ligand-binding experiments.

T L Lai; L Zhang

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PubMed · 7981398

Statistical analysis of ligand-binding experiments.

T L Lai·L Zhang

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Abstract

After a brief review of commonly used methods for parameter estimation from ligand-binding data in the biochemistry literature, we propose some diagnostic checks and statistical tests of the underlying assumptions and develop methods for evaluating the biases and variances of the estimates and for constructing confidence intervals. Examples on the analysis of data from two radioligand-binding experiments are presented to illustrate these methods.

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Animals Binding Sites Cell Membrane Iodine Radioisotopes Kidney Cortex Kinetics Ligands Models, Statistical Probability Protein Binding Radioligand Assay Rats Receptors, Tumor Necrosis Factor Regression Analysis Tumor Necrosis Factor-alpha Yohimbine Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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T L Lai, L Zhang. 1994. Statistical analysis of ligand-binding experiments.. https://pubmed.ncbi.nlm.nih.gov/7981398/

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