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PubMed · 7983587

Biocompatible polyurethane-based hydrogel.

J A Braatz
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Abstract

A polyurethane polymer developed at W. R. Grace has been evaluated for a variety of biomedical applications. The primary property of the polymer exploited for these applications is its ability to prevent protein adsorption when coated on a surface. The prepolymer consists of a trifunctional poly(ethyleneoxide-propylene oxide) triol end capped with isophorone diisocyanate. The prepolymer is reactive with water and can be converted to a hydrogel, a thin coating, or a soluble conjugate with another compound. Each category lends itself to separate biomedical applications which are described in detail. The non-toxic nature of the polymer was demonstrated in a number of systems and suggests its utility in biomedical applications.

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AdsorptionAnimalsAntigensBiocompatible MaterialsContact LensesGelsGrowth SubstancesHalf-LifeHydrogel, Polyethylene Glycol DimethacrylateIsocyanatesMaterials TestingPolyethylene GlycolsPolyethylenesPolypropylenesPolyurethanesProteinsSilicon DioxideSolubilitySurface PropertiesSurface-Active AgentsToluene 2,4-DiisocyanateJournal Article

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J A Braatz. 1994. Biocompatible polyurethane-based hydrogel.. https://doi.org/10.1177/088532829400900104

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Adsorption↗
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