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Nerve growth factor: pathophysiological and therapeutic implications.

R Hellweg·G Raivich
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Abstract

Neurotrophic factors are target-derived proteins capable of affecting survival, target innervation, and/or function of neuronal cell populations. Nerve growth factor (NGF) is the best-studied member of the genetic family called neurotrophins. There is however little knowledge whether other neurotrophins play a pathophysiological role in diseases of the peripheral and central nervous system. An increasing number of animal studies suggest that NGF plays a role in (a) peripheral nerve regeneration, (b) diabetic neuropathy, and (c) age-related neurodegenerative processes within the brain.

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R Hellweg, G Raivich. 1994. Nerve growth factor: pathophysiological and therapeutic implications.. https://doi.org/10.1055/s-2007-1014319

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