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PubMed · 7985097

Apparent lymph node primary gastrinoma.

W S Arnold·D L Fraker·H R Alexander·H C Weber·J A Norton·R T Jensen
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Abstract

BACKGROUND: The existence of lymph node (LN) primary gastrinoma as a cause of Zollinger-Ellison syndrome is controversial. We reviewed our experience with patients in whom gastrinomas were identified and excised only from LNs. METHODS: From 1982 to 1992, 110 patients with ZES underwent exploration for gastrinoma and 21 (19%) had disease limited to one or more LNs. Standardized exploration included intraoperative ultrasonography, intraoperative endoscopy with transillumination and exploratory duodenotomy in 86%, 67%, and 24% of patients, respectively. Each patient underwent yearly biochemical and radiologic follow-up. RESULTS: Thirteen patients (62%) with a median follow-up period of 5.8 years had an initial biochemical cure, whereas eight patients (38%) with a median follow-up period of 3.6 years had persistent disease. Of the 13 patients whose condition initially returned to normal, four have had biochemical recurrence, with a median time to recurrence of 4.2 years and a median follow-up period of 7.4 years. Nine patients (43%) remain biochemically cured, with a median follow-up period of 5.3 years. CONCLUSIONS: Resection of apparent LN primary gastrinoma is warranted, because 43% of those who underwent resection had no evidence of disease, with a median follow-up period of 5.3 years.

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AdultAgedFemaleFollow-Up StudiesGastrinomaHumansLymph NodesMaleMiddle AgedPancreatic NeoplasmsZollinger-Ellison SyndromeJournal ArticleReview

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W S Arnold, D L Fraker, H R Alexander, H C Weber, J A Norton, R T Jensen. 1994. Apparent lymph node primary gastrinoma.. https://pubmed.ncbi.nlm.nih.gov/7985097/

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