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PubMed · 7988949

Experimental models for antiphospholipid studies.

A E Gharavi·A L Aron
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Abstract

Three types of Experimental Animal Models have been used to investigate APA. 1) Passive transfer of APA to nocive mice. Branch et al injected pregnant Balb/c mice with purified IgG APA from patients with recurrent fetal loss. 2) Active immunization with APA. Backimer et al immunized Balb/c mice with a human monoclonal APA carrying the pathogenic idiotypes. 3) Immunization with beta 2 glycoprotein I (beta 2 GPI) (APA cofactor). Using affinity chromatography, we separated two distinct populations of antibodies. One was specific for beta 2GPI without binding to PL. Another population had a dual specificity for PL and beta 2GPI.

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Abortion, HabitualAnimalsAntibodies, AntiphospholipidAntibodies, MonoclonalAntiphospholipid SyndromeAutoimmune DiseasesChromatography, AffinityDisease Models, AnimalFemaleFetal ResorptionGlycoproteinsImmunization, PassiveImmunoglobulin GImmunoglobulin IdiotypesMaleMiceMice, Inbred BALB CMice, Inbred NZBPhospholipidsPregnancyRabbitsVaccinationbeta 2-Glycoprotein IJournal Article

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A E Gharavi, A L Aron. Experimental models for antiphospholipid studies.. https://doi.org/10.1159/000217102

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