PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 7992946

[Bilateral sensorineural hearing loss after general anesthesia].

A Belan·A Rida·N Hamoud·B Riou·M Vercel
View original source ↗Export metadata ↓

Abstract

A bilateral sensorineural (perceptive) deafness occurred in a 12-year-old girl, following laparoscopic appendicectomy under general anaesthesia not comprising nitrous oxide and low insufflation pressures and a normal haemodynamic status. There was neither a personal nor a familial history of hearing disturbances nor a preoperative intake of ototoxic drugs. The initial loss of 50 dB has been substantiated by evoked auditive potentials. The treatment consisted of hyperbaric oxygenotherapy and vasodilators. The girl recovered completely. Finally the etiology of this complication remained unrecognized. Possibly the CO2 insufflated into the abdominal cavity could be considered. However, its causative effect remains to be proven.

Explore related subjects

Anesthesia, GeneralAppendectomyChildEvoked Potentials, Auditory, Brain StemFemaleHearing Loss, BilateralHearing Loss, SensorineuralHumansLaparoscopyCase ReportsEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A Belan, A Rida, N Hamoud, B Riou, M Vercel. 1994. [Bilateral sensorineural hearing loss after general anesthesia].. https://doi.org/10.1016/s0750-7658(94)80047-2

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies.

BACKGROUND: The arterial pharmacokinetics of ketamine and norketamine enantiomers after racemic ketamine or S-ketamine i.v. administration were evaluated in seven gelding ponies in a crossover study (2-month interval). METHODS: Anaesthesia was induced with isoflurane in oxygen via a face-mask and then maintained at each pony's individual MAC. Racemic ketamine (2.2 mg kg(-1)) or S-ketamine (1.1 mg kg(-1)) was injected in the right jugular vein. Blood samples were collected from the right carotid artery before and at 1, 2, 4, 8, 16, 32, 64, and 128 min after ketamine administration. Ketamine and norketamine enantiomer plasma concentrations were determined by capillary electrophoresis. Individual R-ketamine and S-ketamine concentration vs time curves were analysed by non-linear least square regression two-compartment model analysis using PCNonlin. Plasma disposition curves for R-norketamine and S-norketamine were described by estimating AUC, C(max), and T(max). Pulse rate (PR), respiratory rate (R(f)), tidal volume (V(T)), minute volume ventilation (V(E)), end-tidal partial pressure of carbon dioxide (PE'(CO(2))), and mean arterial blood pressure (MAP) were also evaluated. RESULTS: The pharmacokinetic parameters of S- and R-ketamine administered in the racemic mixture or S-ketamine administered separately did not differ significantly. Statistically significant higher AUC and C(max) were found for S-norketamine compared with R-norketamine in the racemic group. Overall, R(f), V(E), PE'(CO(2)), and MAP were significantly higher in the racemic group, whereas PR was higher in the S-ketamine group. CONCLUSIONS: Norketamine enantiomers showed different pharmacokinetic profiles after single i.v. administration of racemic ketamine in ponies anaesthetised with isoflurane in oxygen (1 MAC). Cardiopulmonary variables require further investigation.

Anesthesia, General↗