PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 7993145

Cisapride.

P M Hubbard
View original source ↗Export metadata ↓

Abstract

Renal patients often complain of vague abdominal symptoms compatible with a gastric motility disorder. Cisapride is a recently available prokinetic agent that improves motility and emptying of the upper gastrointestinal tract in patients on long-term dialysis. The drug is extensively metabolized in the liver producing metabolites with minimal pharmacologic activity. Adverse reactions are primarily gastrointestinal in nature and include abdominal cramps, flatulence, and diarrhea.

Explore related subjects

CisaprideGastroesophageal RefluxHumansPiperidinesRenal DialysisRenal InsufficiencyJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

P M Hubbard. 1994. Cisapride.. https://pubmed.ncbi.nlm.nih.gov/7993145/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1999

Randomised controlled trial of cisapride in preterm infants.

AIM: To determine the effect of cisapride on gastrointestinal motility in preterm infants. METHODS: Cisapride (0.2 mg/kg, 8 hourly ) or placebo was given first for seven days in a double blind randomised crossover study of 10 preterm infants. Gastrointestinal motility was assessed on day 3 of each treatment. The half gastric emptying time (GET1/2) was determined by using ultrasonography to measure the decrease in the gastric antral cross sectional area after a feed. The whole gastrointestinal transit time (WGTT) was assessed by timing the transit of carmine red through the gut. Treatments were compared using the Wilcoxon matched pairs signed ranks test. RESULTS: Median (range) birthweight was 1200 (620, 1450) g and postconceptional age 33 (29, 34) weeks at recruitment. GET1/2 was significantly longer during cisapride treatment than during placebo; the median of the differences (95% confidence interval) was 19.2 (11, 30 minutes, p=0.008). WGTT was also longer during cisapride treatment, but the difference was not significant; the median of the differences was 11(-18, 52 hours, p=0.1). CONCLUSIONS: Cisapride delays gastric emptying and may delay WGTT in preterm infants. Its use to promote gastrointestinal motility in this group cannot be recommended.

Cisapride↗