Detection of genetic interference: simulation studies and mouse data.

D E Weeks; J Ott; G M Lathrop

doi:10.1093/genetics/136.3.1217

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Detection of genetic interference: simulation studies and mouse data.

D E Weeks·J Ott·G M Lathrop

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Abstract

Genetic chiasma interference occurs when the occurrence of one crossover (or chiasma) influences the probability of another crossover occurring nearby. We investigated, by simulation studies, the power of three statistical methods to detect interference. Neither the traditional three-locus method nor a multiplicative model approach are very powerful, while a multilocus-feasible map function approach is more powerful, particularly as the number of loci increases. We show that the power to detect interference is quite sensitive to the underlying type of interference. When we tested for interference in two mouse data sets (from chromosomes 1 and 12), we found significant evidence of positive interference.

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Animals Chromosome Mapping Computer Simulation Crossing Over, Genetic Female Genetic Markers Humans Male Meiosis Mice Mice, Inbred C57BL Models, Genetic Recombination, Genetic Sex Characteristics Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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D E Weeks, J Ott, G M Lathrop. 1994. Detection of genetic interference: simulation studies and mouse data.. https://doi.org/10.1093/genetics%2F136.3.1217

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