PubMed · 8007318
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K Takagi, S Tanaka. 1994. [Chest wall abscess].. https://pubmed.ncbi.nlm.nih.gov/8007318/
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Several proteins of Porphyromonas gingivalis contain multiple copies of a 47 amino acid conserved repeated sequence. A fusion protein was constructed in which the P. gingivalis peptide was fused to the carboxy terminus of the hepatitis B core protein. This fusion protein was expressed in Escherichia coli, purified, and used to vaccinate mice that were later challenged with P. gingivalis W83 using the mouse abscess model. Although the mice were not protected against bacterial challenge, Western blot analysis showed that sera from the mice and from rabbits immunized with the fusion protein reacted with a number of vesicle proteins from P. gingivalis W83. These data suggested that this peptide is recognized by the host's immune system but that the antibodies are not protective.
Orbital complications of sinusitis in children generally occur as a consequence of ethmoid sinusitis due to preferential spread across the lamina papyracea. A case is presented of a subperiosteal abscess (SPA) in the superolateral orbital wall complicating frontal sinusitis in a 6-year-old female. Congenital bony dehiscences exist in the lateral floor of the frontal sinus, which may allow direct spread of infection through to that region. While the general principles of managing orbital complications of sinusitis are applicable, the surgical approach for a SPA complicating frontal sinusitis differs from that of the typical medial SPA, and the clinician should be mindful of this variation when planning surgical treatment.
Invasive infections caused by bacteria and fungi are common complications of intravenous drug abuse. Various vital organs and structures may be affected, e.g. the cardiac valves, the larger arteries, the bones, the joints and the central nervous system. However, due to the high frequency of low-virulent microbes of skin and oral origin, the clinical picture may be atypical with subacute course and few focal signs and symptoms. The complexity of this problem is illustrated by eight cases of serious bacterial and fungal infections recently diagnosed at our hospitals. All patients were HIV negative intravenous heroin addicts. The clinical spectrum was wide and included skin abscesses, pyomyositis, spondylodiscitis, septic arthritis, costal osteomyelitis, infective endocarditis, recurrent bacteraemia, and multiple brain abscesses.