Bladder defense mechanism.

S G Mulholland; C L Parsons; S H Shrom; J J Murphy

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PubMed · 801214

Bladder defense mechanism.

S G Mulholland·C L Parsons·S H Shrom·J J Murphy

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Abstract

In order for micro-organisms to infect the urinary tract they must adhere to the vesical mucosa so that they remain after voiding. Experiments in our laboratory demonstrated that the bladder has a self-protective mechanism capable of preventing bacterial adherence to the surface. Histochemical staining demonstrated that this substance is a mucopolysaccharide. Treatment of the mucosa with acid disrupted the protective layer and resulted in a 20 to 100-fold increase in bacterial adherence. Within 24 hours this layer reappeared and binding was again reduced to normal. This phenomenon was not related to microbial species or metabolic activity.

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Adhesiveness Animals Bacterial Infections Escherichia coli Hydrochloric Acid Klebsiella pneumoniae Male Mucous Membrane Rabbits Staphylococcus aureus Urinary Bladder Journal Article

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S G Mulholland, C L Parsons, S H Shrom, J J Murphy. 1976. Bladder defense mechanism.. https://pubmed.ncbi.nlm.nih.gov/801214/

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