Catalytic antibodies: perusing combinatorial libraries.

B Posner; J Smiley; I Lee; S Benkovic

doi:10.1016/0968-0004(94)90273-9

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Catalytic antibodies: perusing combinatorial libraries.

B Posner·J Smiley·I Lee·S Benkovic

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Abstract

Combinatorial libraries are a promising alternative for isolating catalytic antibodies produced by the immune system in response to the transition-state analog of a given reaction. Large, diverse panels of antibodies with high affinity for the transition-state analog can be isolated using screening or selection approaches. Furthermore, we have estimated that nucleotide sequences that bear close similarity to the sequence for a known catalytic antibody occur in combination at frequencies sufficient for their detection in such libraries.

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Amino Acid Sequence Antibodies, Catalytic Gene Library Molecular Sequence Data Molecular Structure Recombinant Fusion Proteins Recombinant Proteins Journal Article Review

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B Posner, J Smiley, I Lee, S Benkovic. 1994. Catalytic antibodies: perusing combinatorial libraries.. https://doi.org/10.1016/0968-0004(94)90273-9

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