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PubMed · 8022616

Endolymphatic sac enhancement.

Abstract

Endolymphatic sac enhancement surgery has proved, over the last several decades, to be a conservative and relatively safe procedure for patients in whom extensive empirical medical therapy has failed. The operation can usually be done as an outpatient procedure or with a one-night postoperative stay, and it has relatively low morbidity. Up to 90% of patients exhibit significant improvement of their episodic vertigo after the operation. Destructive procedures such as labyrinthectomy and vestibular neurectomy are reserved for rare cases of failure of the endolymphatic sac enhancement and are not offered to patients as a primary surgical alternative. Wide decompression of the mastoid and sigmoid sinus is of paramount importance in achieving an adequate endolymphatic sac enhancement. At the end of the operation, meticulous attention should be given to cleaning bone dust and debris from the wound and to stopping all bleeding and bony oozing. Wide opening of the posterior aditus and facial recess is usually necessary to prevent postoperative aditus block. In the postoperative period, scrupulous attention should be given to wound healing; if infection develops in the wound, aggressive antibiotic therapy should be administered to prevent labyrinthitis that could result in deafness.

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BibTeXRIS

M M Paparella, H Sajjadi. 1994. Endolymphatic sac enhancement.. https://pubmed.ncbi.nlm.nih.gov/8022616/

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Endolymphatic sac revision for recurrent intractable Meniere's disease.

Meniere's disease can be observed uniquely in revisions of the conservative surgical procedure for endolymphatic sac enhancement, which preserves the labyrinth, unlike destructive procedures. Genetic anatomic abnormalities in patients lead to malabsorption of endolymph and symptoms of Meniere's that are reversed by endolymphatic sac enhancement, but disabling symptoms eventually may recur in a few cases and require revisional surgery. We observe developing pathophysiologic conditions intraoperatively and have modified our techniques to accommodate the redeveloped pathogenesis we observe and avoid complications found with earlier techniques. This conservative treatment allows patients (many of whom may develop bilateral Meniere's) to retain capacity to accept cochlear implants should they become advisable later.

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Natriuretic peptide receptors in the human endolymphatic sac.

OBJECTIVE: To examine human endolymphatic sac (ELS) tissue for atrial natriuretic peptide (ANP) receptor subtypes A, B, and C. DESIGN: Pilot study. METHODS: Immunohistochemical analysis of human ELS tissue specimens. The ANP receptors were characterized using the peroxidase/antiperoxidase method and polyclonal antibodies directed against each receptor subtype. The identity of the stain regarding receptor subclass was masked from the observer. Human kidney tissue known to contain all 3 receptor subtypes was used as a control. Presence of the receptor subclasses was confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) techniques. SUBJECTS: Samples of ELS tissue were obtained at autopsy from 3 fresh cadaver specimens (6 ears) and as surgical specimens from 3 patients (1 for immunohistochemical analysis and 2 for RT-PCR) undergoing acoustic neuroma resection using the translabyrinthine approach. RESULTS: The ANP type B receptors demonstrated moderate to strong reactivity in all 7 specimens, and mild to moderate staining to the ANP type C receptor was also noted. No appreciable reactivity to the ANP type A receptor was detected using immunohistochemical techniques. All 3 receptor subclasses were detected using RT-PCR. CONCLUSIONS: The ANP receptors are found within the human ELS, with a predominance of ANP type B based on the intensity of staining. The ANPs may be involved in fluid homeostasis in the inner ear. Based on these findings, C-type natriuretic peptide may be a more effective peptide within the human ELS for fluid regulation because its binding affinity is virtually exclusive for the ANP type B receptor.

Endolymphatic Sac↗