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PubMed · 8022755

Beta-cell function in pancreatic adenocarcinoma.

D Basso·M Plebani·P Fogar·G Del Favero·G Briani·T Meggiato·M P Panozzo·C Ferrara·F D'Angeli·A Burlina
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Abstract

To evaluate beta-cell function in patients with pancreatic cancer, the glucagon stimulation test was performed in seven patients with pancreatic adenocarcinoma, seven patients with type I diabetes mellitus, seven patients with type II diabetes mellitus, and in seven healthy controls. C-peptide serum levels were determined before and after a 1-mg i.v. glucagon injection. Basal C-peptide values were normal or slightly increased in pancreatic cancer and type II diabetic patients and low in type I diabetic patients. Following glucagon stimulation, no significant increase was observed in C-peptide values of type I diabetics and pancreatic cancer patients, whereas significant increases occurred in controls and type II diabetics. It is concluded that the altered beta-cell function found in pancreatic cancer patients may lead to hyperglycemia, which is frequently associated with this tumor type.

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AdenocarcinomaAdultC-PeptideFemaleGlucagonHumansMaleMiddle AgedPancreatic NeoplasmsJournal Article

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BibTeXRIS

D Basso, M Plebani, P Fogar, G Del Favero, G Briani, T Meggiato, M P Panozzo, C Ferrara, F D'Angeli, A Burlina. 1994. Beta-cell function in pancreatic adenocarcinoma.. https://doi.org/10.1097/00006676-199405000-00008

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