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PubMed · 8023217

Hydroxyurea-induced acute interstitial lung disease.

M S Kavuru·T Gadsden·A Lichtin·G Gephardt
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Abstract

Hydroxyurea is a cytotoxic agent that is being increasingly used for a number of malignant and nonmalignant systemic diseases. This agent is particularly well tolerated, with dose-related myelosuppression being the primary side effect. We describe a patient who had patchy interstitial infiltrates with cavitation 2 months after the start of therapy with hydroxyurea. After hydroxyurea therapy was discontinued and empiric corticosteroid therapy was given, the pulmonary infiltrates resolved. This is a case of presumed hydroxyurea-induced lung disease, the first with supportive lung biopsy material. It is essential for physicians to be aware of this potentially life-threatening toxicity.

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Acute DiseaseAgedBiopsyFemaleHumansHydroxyureaLungLung Diseases, InterstitialPrednisoloneCase ReportsJournal Article

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BibTeXRIS

M S Kavuru, T Gadsden, A Lichtin, G Gephardt. 1994. Hydroxyurea-induced acute interstitial lung disease.. https://doi.org/10.1097/00007611-199407000-00022

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