[Progress in the red cell substitutes (artificial red cells)].

E Tsuchida

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PubMed · 8028190

[Progress in the red cell substitutes (artificial red cells)].

E Tsuchida

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Abstract

Recent progress of red cell substitutes to apply clinical use are overviewed. In response to the requisites as oxygen transporters, characteristics and present status are summarized for hemoglobin-based substitutes (polymer-conjugated Hb, polymerized Hb, crosslinked Hb). Concentrated hemoglobin covered with thin phospholipid bimolecular layer membranes (hemoglobin-vesicle) transports the sufficient amount of oxygen with excellent solution properties and safety. Furthermore, performances of two types of totally synthetic oxygen carrier are introduced such as lipid-heme embedding in the bilayer of a phospholipid vesicle and lipid-heme in the fat-microsphere composed of the emulsion for the nutrimental infusions.

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Animals Biological Transport Blood Substitutes Hemoglobins Humans Macromolecular Substances Membranes, Artificial Oxygen Particle Size Phospholipids Recombinant Proteins English Abstract Journal Article Review

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E Tsuchida. 1994. [Progress in the red cell substitutes (artificial red cells)].. https://pubmed.ncbi.nlm.nih.gov/8028190/

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