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PubMed · 8028193

[Current scopes on tissue factor: its physiological function and relationship with coagulation diseases].

S Nakamura
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Abstract

Monocytes/macrophages and endothelial cells express tissue factor (TF), an initiator for blood clotting pathway, following their activation accompanied by immune response and/or inflammation. This TF expression results in thrombin generation and fibrin formation around these cells and possibly participates in host-defense mechanism. TF expression by these cells is also a risk-factor to vascular diseases including arteriosclerosis and thrombosis. In cancer and leukemia patients elevation of their plasma TF level associated with DIC and related coagulation disorders.

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AnimalsBlood Coagulation DisordersHumansImmunity, CellularThrombinThromboplastinVascular DiseasesEnglish AbstractJournal ArticleReview

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S Nakamura. 1994. [Current scopes on tissue factor: its physiological function and relationship with coagulation diseases].. https://pubmed.ncbi.nlm.nih.gov/8028193/

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