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PubMed · 8032196

Intergenic DNA and the sequence requirements for replication initiation in eukaryotes.

B J Brewer
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Abstract

Replication in eukaryotes initiates at many origins per chromosome. The locations of most of these origins appear to be restricted to intergenic spacers. In this review, I propose that the sequence dependence of initiation seen in lower eukaryotes may be a by-product of the small size of intergenic sequences and may not reflect a general requirement of the mechanisms that control the initiation of replication.

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Base SequenceDNADNA ReplicationDNA, FungalEukaryotic CellsHumansMolecular Sequence DataSaccharomyces cerevisiaeTranscription, GeneticJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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B J Brewer. 1994. Intergenic DNA and the sequence requirements for replication initiation in eukaryotes.. https://doi.org/10.1016/s0959-437x(05)80045-0

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