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PubMed · 8032715

Human interleukin 4.

J Banchereau·F Brière·J P Galizzi·P Miossec·F Rousset
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Abstract

Human IL-4 is a mature glycoprotein of 129 amino acids, mostly secreted by activated T cells. It is a pleiotropic cytokine which acts on T and B lymphocytes, monocytes, polymorphonuclears, fibroblasts and endothelial cells. In addition, it acts at various stages of cell differentiation, and its effects are also dependent on the cytokine environment. In particular, IL-4 blocks some of the effects of IL-2 whereas interferon-gamma blocks some of the effects of IL-4. In vitro and in vivo experiments in mouse and in vitro experiments in man have shown that IL-4 plays a crucial role in the induction of IgE production whereas interferons counteract this effect. Human IL-4 binds to a high-affinity receptor which is composed at least of one 130 kDa glycoprotein of 800 amino acids which is a member of the newly described hematopoietin receptor superfamily. IL-4 may prove useful as an anti-tumoral and anti-inflammatory agent.

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B-LymphocytesCell DifferentiationEndothelium, VascularFibroblastsHumansInterleukin-4LeukocytesLymphocyte ActivationModels, BiologicalReceptors, Interleukin-4Receptors, MitogenT-LymphocytesJournal ArticleReview

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J Banchereau, F Brière, J P Galizzi, P Miossec, F Rousset. 1994. Human interleukin 4.. https://pubmed.ncbi.nlm.nih.gov/8032715/

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