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PubMed · 8040972

Regulating syringe exchange programs: a cautionary note.

D C Des Jarlais·D Paone·S R Friedman·N Peyser·R G Newman
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HIV InfectionsHumansNeedlesRisk-TakingSubstance Abuse, IntravenousSyringesLetter

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D C Des Jarlais, D Paone, S R Friedman, N Peyser, R G Newman. 1994-08-10. Regulating syringe exchange programs: a cautionary note.. https://doi.org/10.1001/jama.1994.03520060029016

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HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data.

BACKGROUND: Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining TSI give a binary classification of infections as recent or non-recent within a window of several months, and cannot assess the cumulative impact of an intervention. RESULTS: We developed a Random Forest Regression model, HIV-phyloTSI, which combines measures of within-host diversity and divergence to generate continuous TSI estimates directly from viral deep-sequencing data, with no need for additional variables. HIV-phyloTSI provides a continuous measure of TSI up to 9 years, with a mean absolute error of less than 12 months overall and less than 5 months for infections with a TSI of up to a year. It performs equally well for all major HIV subtypes based on data from African and European cohorts. CONCLUSIONS: We demonstrate how HIV-phyloTSI can be used for incidence estimates on a population level.

HIV Infections↗