Cognitive dysfunction associated with biological response modifier therapy.

Abstract

PURPOSE/OBJECTIVES: To review current knowledge regarding the cognitive dysfunction related to administration of biological response modifiers (BRMs), including assessment and nursing intervention. DATA SOURCES: Published studies of cognitive dysfunction in people receiving BRMs, including research based on clinical observation and using pre- and post-treatment measures of cognitive and neurologic function. DATA SYNTHESIS: BRM-associated cognitive dysfunction is a significant clinical problem; however, its mechanisms of action are poorly understood. Clinical observation of patients cognitive and neurologic assessment, and interventions based on presence of premonitory symptomatology are warranted. CONCLUSIONS: Continued research into the causes of this problem and the definition of intervention protocols is needed. IMPLICATIONS FOR NURSING PRACTICE: Anticipatory care including assessing for early identification and family involvement in monitoring for changes, performing structured assessment of cognitive function, ensuring patient safety and reorientation, if necessary, and minimizing sleep disturbances.