Artemisinin: large community studies.

F Nosten

doi:10.1016/0035-9203(94)90472-3

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Artemisinin: large community studies.

F Nosten

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Abstract

Prospective randomized trials with oral artemisinin derivatives have been conducted in over 1000 patients to determine the optimum treatment of multi-drug resistant falciparum malaria on the Thai-Burmese border. These drugs have proved valuable in 3 settings. (i) Primary treatment of uncomplicated malaria in combination with mefloquine, when they accelerate the rate of recovery, eliminate the risk of dangerous early failures, and if given for 3 d or more improve overall cure rates; (ii) treatment of recrudescent infections, which otherwise have a high failure rate; and (iii) oral treatment of patients with high parasitaemias (> or = 4%) but no clinical evidence of severity (a group who would usually receive parenteral quinine). The parenteral formulation of artemether is absorbed if given rectally, and this may offer a practical alternative method of treating severe malaria in rural areas.

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Administration, Oral Antimalarials Antiprotozoal Agents Artemether Artemisinins Artesunate Drug Combinations Drug Resistance Humans Malaria, Falciparum Mefloquine Prospective Studies Sesquiterpenes Suppositories Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial

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F Nosten. 1994. Artemisinin: large community studies.. https://doi.org/10.1016/0035-9203(94)90472-3

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