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Integrated human genome-wide maps constructed using the CEPH reference panel.

K H Buetow·J L Weber·S Ludwigsen·T Scherpbier-Heddema·G M Duyk·V C Sheffield·Z Wang·J C Murray
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Abstract

High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi-automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence "skeletal" set composed of 544 PCR based markers, and a more highly annotated "framework" set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.

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AlgorithmsChromosome MappingChromosomes, HumanDatabases, FactualFemaleFranceGenetic MarkersGenome, HumanHumansInformation ServicesMalePedigreePolymerase Chain ReactionPolymorphism, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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K H Buetow, J L Weber, S Ludwigsen, T Scherpbier-Heddema, G M Duyk, V C Sheffield, Z Wang, J C Murray. 1994. Integrated human genome-wide maps constructed using the CEPH reference panel.. https://doi.org/10.1038/ng0494-391

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