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Consequences of trauma: systemic inflammation and multiple organ dysfunction.

L Fitzsimmons
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Abstract

Critically injured patients are at risk for systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). MODS is a clinical syndrome of progressive physiologic dysfunction of organ systems. Trauma patients are at high risk for SIRS/MODS because of circulatory shock with tissue hypoxemia, tissue injury, and infection. Organ dysfunction may be a direct consequence of an insult (primary MODS) or may manifest latently (secondary MODS) and involves organs not initially injured. Management of SIRS/secondary MODS requires control/elimination of the source of inflammation, maintenance of tissue oxygenation, nutritional/metabolic support, support for individual organs, and effective pain control.

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HumansInflammationMultiple Organ FailureWounds and InjuriesJournal ArticleReview

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BibTeXRIS

L Fitzsimmons. 1994. Consequences of trauma: systemic inflammation and multiple organ dysfunction.. https://doi.org/10.1097/00002727-199408000-00008

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