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PubMed · 8056412

Acute necrotizing pancreatitis: a multicenter study.

L Fernández-Cruz·S Navarro·R Valderrama·A Sáenz·L Guarner·L Aparisi·A Espi·E Jaurietta·L Marruecos·J Gener
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Abstract

A multicenter study of acute necrotizing pancreatitis (ANP) classified in accordance with the Balthazar criteria (grades D and E), has been performed in 12 teaching hospitals. A total of 233 patients were reviewed, and the mortality rate was 26.6%. The most common etiology was biliary pancreatitis (45.5%). Among the complications, shock, renal insufficiency, pulmonary insufficiency and hemorrhagic gastritis were associated with a mortality rate of 51-66%. Diffuse fluid collections were associated with a higher mortality rate (26.8%) than localized fluid collections (14.5%). In 106 patients with gallstone pancreatitis, early surgery was performed in 17, and 5 patients (29.4%) died. No mortality was observed in 32 patients with delayed surgery. Sphincterotomy was performed in 13 patients, and 4 (30.7%) died. Early surgery (necrosectomy and closed peritoneal lavage) was undertaken in 75 patients, with a mortality rate of 39%. In conclusion, the morbidity and mortality rates of ANP can be improved with proper monitoring, adequate supportive care and the judicious use of surgery based on clinical and morphological findings.

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Acute DiseaseAdolescentAdultAgedAged, 80 and overChi-Square DistributionFemaleHumansLogistic ModelsMaleMiddle AgedNecrosisPancreatitisProportional Hazards ModelsRisk FactorsSpainJournal ArticleMulticenter Study

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L Fernández-Cruz, S Navarro, R Valderrama, A Sáenz, L Guarner, L Aparisi, A Espi, E Jaurietta, L Marruecos, J Gener. 1994. Acute necrotizing pancreatitis: a multicenter study.. https://pubmed.ncbi.nlm.nih.gov/8056412/

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