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Self-diffusion in CNS tissue by volume-selective proton NMR.

M A Horsfield·G J Barker·W I McDonald
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Abstract

We have used a volume-selective NMR pulse sequence to measure the diffusion coefficient (D) inside a selected cuboid volume. The sequence is a variant of the stimulated echo method for volume-selective spectroscopy, and allows sequential measurement of D in any of three orthogonal directions and for a range of diffusion times. The echo attenuation from which D is calculated is free from the cross terms that can arise because of interactions between volume selection and diffusion-sensitizing gradients. Anisotropic and diffusion-time-dependent behavior is observed in brain structures known to have axon fibers aligned primarily in one direction.

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AxonsBody TemperatureBrainBrain StemCerebrospinal FluidChloridesCorpus CallosumDiffusionHumansImage EnhancementMagnetic Resonance ImagingMagnetic Resonance SpectroscopyManganese CompoundsModels, StructuralProtonsJournal ArticleResearch Support, Non-U.S. Gov't

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M A Horsfield, G J Barker, W I McDonald. 1994. Self-diffusion in CNS tissue by volume-selective proton NMR.. https://doi.org/10.1002/mrm.1910310609

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