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PubMed · 8073086

Antimicrobial agents from Heterotheca inuloides.

I Kubo·H Muroi·A Kubo·S K Chaudhuri·Y Sanchez·T Ogura
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Abstract

By bioassay directed fractionation, four sesquiterpenoids 1-4 were isolated as antimicrobial agents from the dried flowers of Heterotheca inuloides, a Mexican medicinal plant locally known as "arnica". 7-Hydroxy-3,4-dihydrocadalin (3) and 7-hydroxycadalin (4) exhibited potent antibacterial activity against Gram-positive bacteria with minimum inhibitory concentrations (MICs) ranging from 6.25 to 12.5 micrograms/ml. Notably, 7-hydroxy-3,4-dihydrocadalin showed bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum bactericidal concentration (MBC) of 12.5 micrograms/ml.

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Anti-Bacterial AgentsMicrobial Sensitivity TestsPlants, MedicinalJournal Article

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BibTeXRIS

I Kubo, H Muroi, A Kubo, S K Chaudhuri, Y Sanchez, T Ogura. 1994. Antimicrobial agents from Heterotheca inuloides.. https://doi.org/10.1055/s-2006-959462

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