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PubMed · 8077896

An interaction between Gemfibrozil and alpha 1-antitrypsin.

S Janciauskiene·S Eriksson
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Abstract

Previous studies have demonstrated such hydrophobic compounds as cholesterol and lithocholic acid, to interact with alpha 1-antitrypsin (alpha 1-AT). We observed a similar interaction between the anionic, hydrophobic lipid-lowering drug Gemfibrozil and alpha 1-AT in a deficient (PiZZ) patient, affecting the physicochemical and antiproteinase properties of the inhibitor protein. Gemfibrozil treatment in non-PiZ patients also resulted in a reduction of alpha 1-AT activity which could be reproduced in vitro.

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Drug InteractionsGemfibrozilHumansHyperlipidemiasMaleMiddle AgedObesityalpha 1-AntitrypsinCase ReportsJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

S Janciauskiene, S Eriksson. 1994. An interaction between Gemfibrozil and alpha 1-antitrypsin.. https://doi.org/10.1111/j.1365-2796.1994.tb00809.x

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