Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.

S Kyuwa; M Cohen; G Nelson; S M Tahara; S A Stohlman

doi:10.1128/jvi.68.10.6815-6819.1994

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PubMed · 8084020

Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.

S Kyuwa·M Cohen·G Nelson·S M Tahara·S A Stohlman

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Abstract

Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced only slightly. By contrast, the mRNA levels of interleukin 1 beta, colony-stimulating factor 1 receptor, and tumor necrosis factor alpha increased following infection.

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Actins Animals Antibodies, Monoclonal Antibody Specificity Cell Line Cell Membrane Coronavirus Histocompatibility Antigens Class I Interleukin-1 Kinetics L Cells Mice RNA, Messenger RNA, Viral Receptor, Macrophage Colony-Stimulating Factor Time Factors Tumor Necrosis Factor-alpha Journal Article Research Support, U.S. Gov't, P.H.S.

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S Kyuwa, M Cohen, G Nelson, S M Tahara, S A Stohlman. 1994. Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.. https://doi.org/10.1128/jvi.68.10.6815-6819.1994

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