Combinatorial signaling in development.

R A Cornell; D Kimelman

doi:10.1002/bies.950160811

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PubMed · 8086006

Combinatorial signaling in development.

R A Cornell·D Kimelman

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Abstract

Intercellular signaling plays a major role in the development of vertebrate and invertebrate embryos. In several cases, including the induction of mesoderm and neural ectoderm induction in Xenopus and the induction of the vulva in C. elegans, multiple intercellular signals are utilized. This review examines a number of examples of signaling in development wherein two signals combine to affect the fate of a cell. The examples are placed in distinct categories, based on whether the signals synergize with or antagonize one another, and on the inductive potential of the individual signals. These types of combinatorial signaling events are suggested to be a general feature of embryonic development.

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Animals Caenorhabditis elegans Embryonic Induction Mesoderm Models, Biological Xenopus laevis Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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R A Cornell, D Kimelman. 1994. Combinatorial signaling in development.. https://doi.org/10.1002/bies.950160811

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