A neuronal nucleolar trigger mechanism traceable by a routine staining method.

B Iyengar

doi:10.1159/000145660

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A neuronal nucleolar trigger mechanism traceable by a routine staining method.

B Iyengar

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Abstract

In experimental Wilson's disease produced by the intracardiac injection of copper sulphate, it is seen that the glia-neuronal interactions play an important role in the pathogenesis of neural lesions. A "trigger" copper-RNA particle is transferred from the oligodendroglial nucleus to activate the neuronal nucleolus causing a flooding of the neurone with RNA. This trigger particle stains differently with Mason's trichrome, giving a bright red colour. This altered reaction gives an insight into the feedback process for the formation of ribosomal RNA in the neurones. The alteration appears to lead to a block in the repressor activity of the neuronal RNA formation.

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Animals Brain Cell Nucleolus Cell Nucleus Copper Cytoplasm Hepatolenticular Degeneration Histocytochemistry Neuroglia Neurons Nissl Bodies Oligodendroglia RNA RNA, Ribosomal Rats Staining and Labeling Journal Article

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B Iyengar. 1978. A neuronal nucleolar trigger mechanism traceable by a routine staining method.. https://doi.org/10.1159/000145660

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