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Differential decrease of copper content and of copper binding to superoxide dismutase in liver, heart and brain of copper-deficient rats.

L Rossi·M R Ciriolo·E Marchese·A De Martino·M Giorgi·G Rotilio
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Abstract

Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an apo-form of superoxide dismutase, which can be reactivated by addition of exogenous copper to tissue extracts. These results demonstrate in vivo that superoxide dismutase is post-translationally modulated by copper in higher vertebrates as previously found for yeast and mammalian cells in culture.

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AnimalsBrainCatalaseCeruloplasminCopperElectron Spin Resonance SpectroscopyGlutathione PeroxidaseLiverMaleMyocardiumProtein Processing, Post-TranslationalRatsRats, WistarSeleniumSuperoxide DismutaseJournal ArticleResearch Support, Non-U.S. Gov't

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L Rossi, M R Ciriolo, E Marchese, A De Martino, M Giorgi, G Rotilio. 1994-09-15. Differential decrease of copper content and of copper binding to superoxide dismutase in liver, heart and brain of copper-deficient rats.. https://doi.org/10.1006/bbrc.1994.2285

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