Immunosuppression effected by macrophage surfaces.

W Ptak; R K Gershon

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PubMed · 809511

Immunosuppression effected by macrophage surfaces.

W Ptak·R K Gershon

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Abstract

Heat-killed macrophages (but not six other types of cells tested) suppress Mishell-Dutton cultures by a mechanism that does not adversely affect cell viability. The suppressive effect is abolished by treatments that inactivate receptors for cytophilic antibody. We suggest macrophages may absorb, and thus render inoperative, factors which are necessary for lymphocyte cooperation.

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Animals Ascitic Fluid Cell Membrane Glutaral Hemolytic Plaque Technique Hot Temperature Immunosuppression Therapy In Vitro Techniques Macrophages Male Mice Mice, Inbred CBA Neuraminidase Spleen Trypsin Journal Article Research Support, U.S. Gov't, P.H.S.

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W Ptak, R K Gershon. 1975. Immunosuppression effected by macrophage surfaces.. https://pubmed.ncbi.nlm.nih.gov/809511/

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