Purified antichick Thy-1 IgG abolishes intermediate and long-term memory.

H Feng; W Q Zhao; C C Bernard; K T Ng; G Sedman

doi:10.1016/0031-9384(93)90196-m

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Purified antichick Thy-1 IgG abolishes intermediate and long-term memory.

H Feng·W Q Zhao·C C Bernard·K T Ng·G Sedman

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Abstract

One- to 2-day-old chicks administered purified antichick Thy-1 IgG showed substantial amnesia for a single-trial passive discriminated avoidance task. Amnesia was clearly evident at 30 min after learning, during the intermediate stage of a three-stage model of memory processing, and persisted for at least 3 h. A similar effect was also observed with Fab and F(ab')2 fragments. Fc fragments, the non-IgG fraction of ascites, and saline yielded normal retention levels at all times. These results contrast with our earlier reports that both polyclonal and monoclonal antibodies to chick Thy-1 inhibited long-term memory formation only. The present findings are interpreted as possibly representing a dual effect of the purified IgG.

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Animals Antibodies, Monoclonal Antigens, Surface Ascitic Fluid Avoidance Learning Brain Chickens Color Perception Conditioning, Classical Immunoglobulin G Isoantibodies Membrane Glycoproteins Mental Recall Retention, Psychology Synaptic Membranes Taste Thy-1 Antigens Journal Article

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H Feng, W Q Zhao, C C Bernard, K T Ng, G Sedman. 1993. Purified antichick Thy-1 IgG abolishes intermediate and long-term memory.. https://doi.org/10.1016/0031-9384(93)90196-m

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