STE6, the yeast a-factor transporter.

S Michaelis

doi:10.1006/scel.1993.1003

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STE6, the yeast a-factor transporter.

S Michaelis

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Abstract

In eukaryotic cells, most extracellular proteins exit the cell via the classical secretory pathway (ER-->Golgi-->secretory vesicles). A notable exception to this pattern is the Saccharomyces cerevisiae mating pheromone alpha-factor, an isoprenylated, methylated, oligopeptide signaling molecule which uses a distinctly non-classical mechanism for secretion. Export of alpha-factor from the yeast cell is mediated by STE6, a member of the ABC protein superfamily. STE6 is one of the few eukaryotic ABC proteins for which a true physiological substrate is known. The ability to carry out molecular manipulations with ease in yeast, together with the possibility of probing substrate-transporter interactions via genetic analysis, affords an excellent opportunity to rigorously dissect the workings of this ABC family member.

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ATP Binding Cassette Transporter, Subfamily B, Member 1 ATP-Binding Cassette Transporters Amino Acid Sequence Biological Transport, Active Carrier Proteins Drug Resistance Fungal Proteins Glycoproteins Membrane Glycoproteins Molecular Sequence Data Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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S Michaelis. 1993. STE6, the yeast a-factor transporter.. https://doi.org/10.1006/scel.1993.1003

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